Glycated haemoglobin variability and risk of renal function decline in type 2 diabetes mellitus: An updated systematic review and meta‐analysis
Authors' conclusion
The four HbA1c variability indicators were all positively associated with renal function decline progression; therefore, HbA1c variability might play an important and promising role in guiding glycaemic control targets and predicting kidney function decline progression in T2DM.
Study context
- Population
- Patients with T2D; studies searched in PubMed, Embase, Web of Science and the Cochrane Library until 12 March 202418 studies
- Comparison
- High vs low HbA1c variability
- Outcome
- Renal function decline
Methodological detailsrandom-effect models, PRISMA
- Random-effect models
- PRISMA
Pooled result
As reported in the abstract
Kidney function decline
High HbA1c variability vs Low HbA1c variabilityHazard ratio (95% CI)
SD groups
1.26(1.15–1.38)
CV groups
1.47(1.30–1.65)
HVS groups
1.32(1.10–1.57)
HGI groups
1.53(1.05–2.23)
Further pooled results
Kidney function decline per 1% increase in HbA1c SD and coefficient of variation (CV)
- Per 1% increase in SD: HR
- 1.26 (95% CI 1.17-1.35)
- Per 1% increase in CV: HR
- 1.13 (95% CI 1.03-1.23)
Renal function deterioration per 1-SD increase in SD of HbA1c
- HR
- 1.17 (95% CI 1.07-1.29)
Original publication
Glycated haemoglobin variability and risk of renal function decline in type 2 diabetes mellitus: An updated systematic review and meta‐analysis. Diabetes Obes Metab. Published 4 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →