Serum albumin and risk of incident diabetes and diabetic microvascular complications in the UK Biobank cohort
Authors' conclusion
In this large prospective study, serum levels of albumin were inversely associated with the incidences of diabetes and diabetic microvascular complications. These findings underscore the importance of maintaining optimal nutrient status in reducing the risk of diabetes and its complications.
Study context
- Population
- UK Biobank participants without diabetes (398,146) and patients with diabetes (30,952)
- Exposure
- Per 10 g/l increase in serum albumin
- Outcome
- Incident diabetes
- Follow-up
- Median 12.90 years
Methodological detailsUK Biobank, multivariate-adjusted Cox proportional hazard models, Mendelian randomization analysis
- UK Biobank
- Multivariate-adjusted Cox proportional hazard models
- Mendelian randomization analysis
Main finding
As reported in the abstract
median 12.90 years
Participants developing incident diabetes
14,710
HR per 10 g/l increase in serum albumin, multivariate-adjusted
0.88 [0.82;0.94] (95% CI)
Observational data: associations, not effects.
Further findings
Mendelian randomization (MR): genetic influence of serum albumin on diabetes
- OR per 1 g/l increase, UK Biobank
- 0.99 [0.98;1.00] (95% CI)
- OR per 1 g/l increase, FinnGen consortium
- 0.78 [0.67;0.92] (95% CI)
Diabetic microvascular complications in patients with diabetes
- HR per 10 g/l increase, diabetic nephropathy
- 0.42 [0.30;0.58]
- HR per 10 g/l increase, ophthalmopathy
- 0.61 [0.52;0.72]
- HR per 10 g/l increase, neuropathy
- 0.67 [0.51;0.88]
Original publication
Serum albumin and risk of incident diabetes and diabetic microvascular complications in the UK Biobank cohort. Diabetes Metab. Published 6 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →