The Role of a Continuous Glucose Monitoring-Derived Glycation Ratio in the Development of Microvascular Complications
Authors' conclusion
GR may be a useful marker for risk of diabetic microvascular complications.
Study context
- Population
- Patients with diabetes using continuous glucose monitoring (CGM) before the study, University of Washington; diabetes duration >20 years in 59%, median age 45 years
- Participants
- 661 patients
- Exposure
- Glycation ratio as continuous variable, per 0.20-unit increase
- Outcome
- Association of GR with diabetic retinopathy (DR) and diabetic kidney disease (DKD)
Methodological detailsretrospective review, logistic regression
- Retrospective review
- Logistic regression
Main finding
As reported in the abstract
GR per 0.20-unit increaseEstimate (95% CI)P value
38% relative reduction in odds of DR
aOR for DR 0.62(0.45–0.86)
P = 0.004Similar reduction in odds of DKD
OR for DKD 0.61(0.41–0.93)
P = 0.02Per 0.20-unit increase, as printed
Observational data: associations, not effects.
Original publication
The Role of a Continuous Glucose Monitoring-Derived Glycation Ratio in the Development of Microvascular Complications. Diabetes Technol Ther. Published 10 February 2025. doi:10.
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