Sleep duration, mediating biomarkers, and risk of microvascular complications among individuals with type 2 diabetes: A prospective cohort study
Authors' conclusion
Our study demonstrated that both short and long sleep durations were independently associated with increased risk of diabetic microvascular complications. The associations were partially mediated by metabolic biomarkers related to obesity, systemic inflammation, liver function, and lipid profile.
Study context
- Population
- Participants with T2D from the UK Biobank; sleep duration from baseline questionnaire
- Participants
- 24,081 participants
- Exposure
- Sleep duration ≤5 and ≥10 hrs/day vs 7 hrs/day
- Outcome
- Incident composite diabetic microvascular complications
Methodological detailsUK Biobank, Cox regression
- UK Biobank
- Cox regression
Main finding
As reported in the abstract
Composite microvascular complications
Hazard ratio (95 % CI)
≤ 5 hrs/dayvs 7 hrs/day
1.21(1.09–1.35)
≥ 10 hrs/dayvs 7 hrs/day
1.24(1.09–1.42)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95 % CI) | |
|---|---|---|
| DKD≤ 5 hrs/dayvs 7 hrs/day | 1.20 (1.04–1.38) | |
| DKD≥ 10 hrs/dayvs 7 hrs/day | 1.30 (1.09–1.54) | |
| Diabetic neuropathy≤ 5 hrs/dayvs 7 hrs/day | 1.61 (1.30–2.00) | |
| Diabetic neuropathy≥ 10 hrs/dayvs 7 hrs/day | 1.35 (1.01–1.79) | |
| DR≤ 5 hrs/dayvs 7 hrs/day | 1.10 (0.93–1.30) | |
| DR≥ 10 hrs/dayvs 7 hrs/day | 1.17 (0.95–1.44) | |
| 0.512Hazard ratio (log scale) |
Mediation by biomarkers (BMI, gamma-glutamyl transferase, C-reactive protein, alkaline phosphatase, total cholesterol, LDL-C)
- Proportion of sleep duration–composite complications association collectively explained
- 20.34 %
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sleep duration, mediating biomarkers, and risk of microvascular complications among individuals with type 2 diabetes: A prospective cohort study. Diabetes Res Clin Pract. Published 8 February 2025. doi:10.
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