Association Between Continuous Glucose Monitoring-Derived Glycemia Risk Index and Albuminuria in Type 2 Diabetes
Authors' conclusion
GRI is strongly associated with albuminuria, especially macroalbuminuria, in type 2 diabetes.
Study context
- Population
- Individuals with T2D with professional continuous glucose monitoring (CGM) and urinary albumin-to-creatinine ratio (UACR) data
- Participants
- 866 individuals
- Exposure
- Per increase in glycemia risk index (GRI) zone
- Outcome
- Albuminuria (≥1 UACR ≥30 mg/g) associated with GRI
Methodological detailsretrospective review, multiple logistic regression
- Retrospective review
- Multiple logistic regression
Main finding
As reported in the abstract
Albuminuria per increase in GRI zone
aOR of albuminuria per increase in GRI zone
1.13
95% CI 1.02–1.27P = 0.039
Observational data: associations, not effects.
Further findings
Prevalence of albuminuria and macroalbuminuria
- Albuminuria prevalence
- 36.6%
- Macroalbuminuria prevalence
- 13.9%
Hyperglycemia component, GRI score and hypoglycemia component by UACR
- Higher UACR had significantly higher hyperglycemia component and GRI score (all P < 0.001)
- Hypoglycemia component did not differ among groups
Macroalbuminuria (≥1 UACR ≥300 mg/g) per increase in GRI zone
- OR
- 1.42 (95% CI 1.20-1.69, P < 0.001)
- OR after adjusting for HbA1c
- 1.31 (95% CI 1.10-1.58, P = 0.004)
Original publication
Association Between Continuous Glucose Monitoring-Derived Glycemia Risk Index and Albuminuria in Type 2 Diabetes. Diabetes Technol Ther. Published 29 August 2023. doi:10.
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