A J‐shaped relationship between ketones and the risk of diabetic kidney disease in patients with type 2 diabetes: New insights from a cross‐sectional study
Authors' conclusion
A J-shaped relationship between circulating ketone level and DKD risk in patients with T2D was determined. Circulating βOHB in the range of 0.12-0.30 mM was associated with a lower risk of DKD. Further studies are warranted to verify the causality and to elucidate the underlying mechanisms.
Study context
- Population
- Patients with T2D
- Participants
- 1,388 patients
- Exposure
- High vs normal circulating βOHB; quartiles of βOHB within normal range
- Outcome
- DKD risk by circulating β-hydroxybutyric acid (βOHB)
Main finding
As reported in the abstract
DKD
Multivariable-adjusted OR (95% CI)P value
Q1vs Q4
2.30(1.62–3.26)
P < 0.001Q2vs Q4
1.80(1.23–2.62)
P < 0.001Q3vs Q4
1.63(1.10–2.41)
P < 0.001- Q4 had the lowest prevalence of diabetic kidney disease (DKD)
- P = 0.001
- DKD risk lowest at serum βOHB 0.183 mM: OR
- 0.63 (0.52-0.77) (95% CI)
Observational data: associations, not effects.
Original publication
A J‐shaped relationship between ketones and the risk of diabetic kidney disease in patients with type 2 diabetes: New insights from a cross‐sectional study. Diabetes Obes Metab. Published 22 August 2023. doi:10.
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