Association between time in tight range and incident diabetic retinopathy in adults with type 2 diabetes
Authors' conclusion
TITR is inversely associated with the incidence of diabetic retinopathy in adults with type 2 diabetes. Among adults with well-controlled TIR (70% or higher), TITR may provide added value regarding glucose control.
Study context
- Population
- Adults with T2D without DR at baseline, tertiary hospital; TITR (70–140 mg/dL) from baseline CGM
- Participants
- 2,518 adults
- Exposure
- TITR quartiles vs highest quartile
- Outcome
- Incident DR
- Follow-up
- Mean 5.43 years
Methodological detailsdynamic cohort, single tertiary hospital
- Dynamic cohort
- Single tertiary hospital
Main finding
As reported in the abstract
Each group vs Q4Multivariable-adjusted HR (95% CI)
Q3
1.47(1.16–1.87)
Q2
1.52(1.20–1.93)
Q1
1.93(1.53–2.43)
- Patients developing retinopathy
- 646
- HR per 10% decrease in TITR, fully adjusted
- 1.09 (95% CI 1.06, 1.13)
Observational data: associations, not effects.
Further findings
DR risk by TIR and TITR in TIR >70% subgroup
- Association of continuous TIR with incident DR disappeared, whereas TITR remained significantly associated
- Similar results in TIR >80% and TIR >90% subgroups
Original publication
Association between time in tight range and incident diabetic retinopathy in adults with type 2 diabetes. Diabetes Obes Metab. Published 18 December 2024. doi:10.
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