Association of Time in Tight Range with Microvascular Complications in Japanese Patients with Type 2 Diabetes Mellitus: A Multicenter Cross-Sectional Study
Authors' conclusion
Higher TITR was significantly associated with lower prevalence of microvascular complications in patients with T2DM. CGM-derived TITR is a potentially useful clinical metric for optimizing glycemic management and reducing the risk of microvascular complications.
Study context
- Population
- Japanese patients with T2D and negative history of CVD; Time in tight range (TITR) (70–140 mg/dL) from continuous glucose monitoring (CGM)
- Participants
- 999 patients
- Exposure
- TITR quartiles
- Outcome
- Any microvascular complication
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
Each group vs Q1Adjusted odds ratio (95% CI)
Q2
0.39(0.25–0.62)
Q3
0.45(0.28–0.70)
Q4
0.30(0.19–0.47)
Observational data: associations, not effects.
Further findings
TITR and prevalence of microvascular complications (overall)
- Mean TITR
- 56.8 ± 22.4%
- ≥1 microvascular complication
- 51.2%
Retinopathy, nephropathy, peripheral neuropathy
- Similar inverse trends across TITR quartiles
- Each 10% increase in TITR associated with reduced risk of each type of microvasculopathy
Optimal TITR cutoff for identifying microvascular complications (ROC analysis)
- Optimal TITR cutoff
- 54.3%
Original publication
Association of Time in Tight Range with Microvascular Complications in Japanese Patients with Type 2 Diabetes Mellitus: A Multicenter Cross-Sectional Study. Diabetes Technol Ther. Published 4 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →