Continuous glucose monitoring-derived time in range and CV are associated with altered tissue characteristics of the carotid artery wall in people with type 2 diabetes
Authors' conclusion
TIR and CV were significantly associated with changes in the tissue characteristics of the carotid artery wall.
Study context
- Population
- People with T2D and no apparent history of symptomatic CVD, undergoing continuous glucose monitoring (CGM) and carotid US (intima-media thickness (IMT), grey-scale median (GSM)) at baseline and 104 weeks
- Participants
- 600 people
- Comparison
- CGM-derived time in range (TIR) and CV vs changes in carotid atherosclerosis indices
- Primary endpoint
- Association of CGM-derived indices, mainly TIR and CV, with changes in carotid atherosclerosis index values
- Follow-up
- 104 weeks
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Mean GSM: regression coefficient per 10% increase in TIR
0.52
95% CI 0.06, 0.98; Hochberg-adjusted p value 0.038
Mean GSM: regression coefficient per 1% increase in CV
−0.12
95% CI −0.22, −0.02; Hochberg-adjusted p value 0.038
Thickened-lesion GSM: regression coefficient per 10% increase in TIR
0.95
95% CI 0.12, 1.79; Hochberg-adjusted p value 0.038
Thickened-lesion GSM: regression coefficient per 1% increase in CV
−0.19
95% CI −0.36, −0.01; Hochberg-adjusted p value 0.038
Further findings
| Outcome | Targets achieved | Targets not achieved | P value |
|---|---|---|---|
| Annual change in mean GSM by achievement of consensus target CGM-derived metrics at baseline | 0.94 ± 6.88 units/year | −0.21 ± 6.19 units/year | P = 0.007 |
Change in carotid indices from baseline to 104 weeks
- Mean IMT
- from 0.759±0.153 to 0.773±0.152 mm, p<0.001
- Thickened-lesion GSM
- from 43.5±19.5 to 53.9±23.5 units, p<0.001
- Common carotid artery maximum-IMT
- from 1.109±0.442 to 1.116±0.469 mm, p=0.453
- Mean GSM
- from 48.7±19.3 to 49.8±20.8 units, p=0.092
Original publication
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