Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus
Authors' conclusion
The findings of this study indicate that the severity of WMLs is associated with TIR and GRI, which are indices of the quality of glycemic control.
Study context
- Population
- Japanese patients with T2D
- Participants
- 150 patients
- Exposure
- Continuous glucose monitoring (CGM)-derived glycemic control indices vs brain imaging biomarkers
- Outcome
- Association between CGM-derived glycemic control indices and MRI brain imaging biomarkers (WML severity, MTA)
Methodological detailsCGM worn for 14 consecutive days; White matter lesions (WMLs) assessed by MRI; MTA by voxel-based morphometry
- CGM worn for 14 consecutive days; WMLs assessed by MRI; MTA by voxel-based morphometry
Main finding
As reported in the abstract
Severe WMLs
- Proportion with severe WMLs decreased with increasing time in range (TIR)
- P for trend=0.006
- Proportion with severe WMLs increased with worsening glycemia risk index (GRI)
- P for trend=0.011
Observational data: associations, not effects.
Further findings
MTA degree
- No significant association between MTA and TIR
- P for trend = 0.325
- No significant association between MTA and GRI
- P for trend = 0.447
Original publication
Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus. BMJ Open Diabetes Res Care. Published 17 January 2024. doi:10.
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