Association of urinary albumin-to-creatinine ratio with cardiometabolic risk markers and pre-diabetes in adults with normoglycemia, normoalbuminuria, and normotension with parental type 2 diabetes
Authors' conclusion
Baseline uACR levels were associated with cardiometabolic risk markers and incident pre-diabetes risk among adults with normoglycemia, normoalbuminuria and normotension with parental diabetes.
Study context
- Population
- Healthy, initially normoglycemic, normotensive, normoalbuminuric African American and European American adults with parental T2D (POP-ABC Study)
- Participants
- 308 participants
- Comparison
- Baseline urinary albumin-to-creatinine ratio (uACR) quartiles in relation to incident pre-diabetes
- Primary endpoint
- Incident pre-diabetes
- Follow-up
- Up to 5.5 years (mean 2.62 years)
Methodological detailsbiracial cohort, quarterly follow-up
- Biracial cohort
- Quarterly follow-up
Primary result
As reported in the abstract
5.5 years of follow-up
Developed pre-diabetes
104 participants
Maintained normoglycemia
204 participants
Association of baseline uACR quartiles with incident pre-diabetes
r=0.19
p=0.0011
Further findings
African American (AA) vs European American (EA)
Baseline uACR, AA vs EA · similar
P = 0.52
Women vs Men
Baseline uACR, women vs men · higher in women
P < 0.0001
Baseline uACR and cardiometabolic risk factors
- Significant associations with age, insulin sensitivity, HDL-C and adiponectin
- P = 0.03-0.004
Original publication
Association of urinary albumin-to-creatinine ratio with cardiometabolic risk markers and pre-diabetes in adults with normoglycemia, normoalbuminuria, and normotension with parental type 2 diabetes. BMJ Open Diabetes Res Care. Published 17 January 2024. doi:10.
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