Sex differences in the prognostic value of urinary albumin-to-creatinine ratio for coronary artery disease and cardiovascular events in people with type 2 diabetes and normoalbuminuria
Authors' conclusion
Within the normoalbuminuric range, UACR is associated with greater CAD burden and higher 6-year MACE risk, with sex-specific differences. These findings suggest potential sex-related variation in the prognostic value of high-normal albuminuria, particularly among women, warranting validation in larger and more diverse cohorts.
Study context
- Population
- Adults with T2D and preserved kidney function (eGFR >60 mL/min/1.73 m², urinary albumin-to-creatinine ratio (UACR) <30 mg/g) undergoing diagnostic coronary angiography; mean age 65.3 ± 10.7 years; median UACR 7.56 mg/g (IQR 4.12–15.5)180 women
- Participants
- 420 adults
- Exposure
- UACR within the normoalbuminuric range, by sex
- Outcome
- Sex differences (co-primary objective) in the association of UACR (KDIGO A1 range) with CAD severity and MACE in women and men with T2DM
- Follow-up
- 6-year
Main finding
As reported in the abstract
Higher log-UACR independently predicted major adverse cardiovascular events (MACE)
aHR 1.67
95% CI 1.35–2.10p < 0.01
Higher incidence of MACE in highest UACR tertile (Kaplan-Meier)
log-rank p = 0.039
Higher UACR independently associated with greater coronary stenosis (adjusted R², p < 0.001)
0.090
Sex-stratified: higher log-UACR predicted MACE in both sexes
aHR 1.67
95% CI 1.35–2.10p < 0.01
Observational data: associations, not effects.
Further findings
Significant coronary artery disease (CAD) · baseline
- Significant CAD
- 310 (73.8%)
- MACE during follow-up
- 78 (35.5%)
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →