Time trends in mortality from heart failure and atherosclerotic cardiovascular disease in people with and without diabetes: a multi-national population-based study
Authors' conclusion
Declines in heart failure mortality in both people with and without diabetes were less marked than were declines in CHD and cerebrovascular disease mortality in most jurisdictions. Heart failure mortality rate ratios have not decreased. A greater focus on reducing heart failure mortality in people with and without diabetes might be required.
Study context
- Population
- Nine high-income jurisdictions (Europe [n=5], Australia [n=1], Canada [n=2], South Korea [n=1]), 2000–231.30 billion person-years
- Exposure
- People with diabetes vs without diabetes
- Outcome
- Trends in CHD, cerebrovascular disease and HF mortality by diabetes status, and mortality rate ratios (diabetes vs no diabetes)
- Follow-up
- 2000-23
Methodological detailsnine administrative datasets, Poisson regression
- Nine administrative datasets
- Poisson regression
Main finding
As reported in the abstract
CVD cause-specific mortality trends
Cardiovascular disease (CVD) deaths
2.92 million
5-year percent changes in coronary heart disease (CHD) mortality
−11.5% to −32.3%
Observational data: associations, not effects.
Original publication
Time trends in mortality from heart failure and atherosclerotic cardiovascular disease in people with and without diabetes: a multi-national population-based study. Lancet Diabetes Endocrinol. Published 6 November 2025. doi:10.
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