Increased high-risk plaque burden in type 2 diabetes: a 10-year follow-up study
Authors' conclusion
Patients with diabetes had a more than threefold higher rate of coronary plaque progression and an increased development of high-risk plaque.
Study context
- Population
- Patients undergoing serial coronary CT angiography, median scan interval 10.2 years; mean age 57 ± 7 years, 43% women; CABG and PCI-revascularized vessels excluded299 scanned, 32 excluded
- Participants
- 267 patients
- Exposure
- T2D vs no diabetes
- Diabetesn = 44
- Outcome
- Baseline coronary plaque characteristics and 10-year plaque progression, incl. high-risk and low-density plaque
- Follow-up
- Median 10.2 [IQR 8.7-11.2] years
Methodological detailsserial coronary CT angiography (CCTA), 10-year follow-up, multivariable regression adjusted for cardiovascular risk factors, statin use, baseline plaque volumes and scanner settings
- Serial CCTA
- 10-year follow-up
- Multivariable regression adjusted for cardiovascular risk factors, statin use, baseline plaque volumes and scanner settings
Main finding
As reported in the abstract
10 years
Diabetes vs Non-diabeticOdds ratio (95% CI)P value
High-risk plaque
2.75(1.38–5.48)
P = 0.004Low-density plaque
2.88(1.45–5.70)
P = 0.002Observational data: associations, not effects.
Further findings
| Outcome | Diabetes | Non-diabetic |
|---|---|---|
| Percent atheroma volume (PAV) · baseline | 5.1% (unspecified 1.7–10.9) | 2.2% (unspecified 0.5–5.8) |
Percent atheroma volume (PAV) · baseline
- Higher plaque burden with diabetes at baseline and follow-up, adjusted for CV risk factors
Original publication
Increased high-risk plaque burden in type 2 diabetes: a 10-year follow-up study. Cardiovasc Diabetol. Published 5 November 2025. doi:10.
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