Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry
Authors' conclusion
Diabetes, but not prediabetes, was independently associated with rapid progression of coronary atherosclerosis.
Study context
- Population
- Subjects from the PARADIGM registry who underwent serial coronary CT angiography with available glycemic data; mean age 61 ± 9 years, 56.9% men; median inter-scan interval 3.2 (IQR 2.6–4.4) years
- Participants
- 1,296 subjects
- Exposure
- Diabetes and prediabetes vs normal glycemic status
- Outcome
- Rapid plaque progression (RPP): increase in percent atheroma volume (PAV) of ≥ 1.0%/year
Methodological detailsserial coronary CT angiography registry, multivariable logistic regression
- Serial coronary CT angiography registry
- Multivariable logistic regression
Main finding
As reported in the abstract
Incidence of RPP
Overall P < 0.001
Observational data: associations, not effects.
Further findings
%/year
| Outcome | Normal glycemic status | Prediabetes | Diabetes | P value |
|---|---|---|---|---|
| Annual change in PAVDiabetes vs Normal glycemic status · across all three glycemic groups | 0.30 (interval 0.00–0.98) | 0.35 (interval 0.04–0.98) | 0.65 (interval 0.19–1.54) | overall P < 0.001 |
| RPP among participants without diabetes at baseline: new-onset diabetes vs no new-onset diabetes | P = 0.039 |
- Rapid plaque progression (RPP) among participants without diabetes at baseline: new-onset diabetes vs no new-onset diabetes: New-onset diabetes 36.1%
- RPP among participants without diabetes at baseline: new-onset diabetes vs no new-onset diabetes: No new-onset diabetes 24.2%
Original publication
Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry. Cardiovasc Diabetol. Published 5 September 2026. doi:10.
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