High‐intensity statin therapy is associated with reduced coronary inflammation on CT in patients with type 2 diabetes mellitus
Authors' conclusion
In patients with T2DM and coronary atherosclerosis, high-intensity statin therapy was associated with lower coronary inflammation. Our findings emphasize the need for aggressive cardiovascular prevention in this high-risk cohort.
Study context
- Population
- Patients with T2D and coronary atherosclerosis on coronary computed tomography angiography (CCTA), treated with ≥1 oral hypoglycaemic agent, no prior coronary interventions; CCTAs 1/1/2019–9/1/2024
- Participants
- 203 CCTAs
- Exposure
- High-intensity vs moderate-intensity statin vs no statin
- High-intensityn = 75
- Outcome
- PCAT attenuation in the proximal right coronary artery (marker of coronary inflammation)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
PCAT attenuation
High-intensity
−75.0
± 6.8 · Hounsfield Units (HU)
Moderate-intensity
−71.8
± 8.2 · HU
No statin
−71.6
± 7.4 · HU
Adjusted p = 0.027
Observational data: associations, not effects.
Further findings
Elevated pericoronary adipose tissue (PCAT) attenuation (≥ −70.5 HU) with GLP-1 RA treatment
- GLP-1 RA independently associated with lower likelihood of elevated PCAT attenuation, OR
- 0.344 (95% CI 0.132-0.900)
Original publication
High‐intensity statin therapy is associated with reduced coronary inflammation on CT in patients with type 2 diabetes mellitus. Diabetes Obes Metab. Published 18 August 2025. doi:10.
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