International Variation in Case Fatality After Major Coronary or Cerebrovascular Events in Individuals With Type 2 Diabetes: Evidence From ADVANCE, TECOS, and EXSCEL
Authors' conclusion
Postcoronary case fatality was substantially higher in Asia, Central and Eastern Europe, and South America and Africa compared with Western countries and higher in low- and middle-income countries compared with high-income countries.
Study context
- Population
- ADVANCE, TECOS and EXSCEL participants with T2D who had within-trial major coronary (fatal or nonfatal MI or sudden cardiac death) or cerebrovascular (fatal or nonfatal stroke) eventspooled ADVANCE, TECOS, EXSCEL
- Participants
- 40,563 participants
- Comparison
- Geographic regions and country income levels vs reference
- Outcome
- Case fatality: death at the time or within 30 days of a major coronary or cerebrovascular event
- Follow-up
- Within 30 days
Methodological detailsindividual participant data meta-analysis, logistic regression, adjusted for previous cardiovascular events and risk factors
- Individual participant data meta-analysis
- Logistic regression
- Adjusted for previous cardiovascular events and risk factors
Pooled result
As reported in the abstract
Postcoronary case fatality
Estimate (95% CI)
Asiavs Western Europe, North America, or Australia and New Zealand
aOR 3.31(2.32–4.72)
Central and Eastern Europevs Western Europe, North America, or Australia and New Zealand
aOR 2.78(2.11–3.66)
South America and Africavs Western Europe, North America, or Australia and New Zealand
aOR 2.84(1.71–4.73)
Low- and middle-incomevs High-income
OR 3.07(2.41–3.92)
- Major coronary events
- 2,574
Further pooled results
Case fatality after major cerebrovascular event · within 30 days
- Major cerebrovascular events
- 1,247
- Did not differ by geographic region or income group
Original publication
International Variation in Case Fatality After Major Coronary or Cerebrovascular Events in Individuals With Type 2 Diabetes: Evidence From ADVANCE, TECOS, and EXSCEL. Diabetes Care. Published 28 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →