Frequency and clinical characteristics of children and young people with type 2 diabetes at diagnosis from five world regions between 2012 and 2021: data from the SWEET Registry
Authors' conclusion
The multinational SWEET data from the years 2012 to 2021 inclusive support recent findings of a worldwide increase in type 2 diabetes in young people, albeit with regional differences. This increase highlights the need for ongoing preventive measures and available advanced treatment modalities worldwide.
Study context
- Population
- Children and young people with new-onset diabetes, SWEET Registry, 130 centres worldwide, 2012–2021
- Participants
- 58,170 new diabetes cases
- Exposure
- Regions: Europe (EU), AU/NZ, South America (SA), North America (NA), AS/AF
- EUn = 614
- AU/NZn = 293
- SAn = 79
- NAn = 1,211
- AS/AFn = 622
- Outcome
- Proportion of new diabetes cases with T2D, trend per two-year period
- Follow-up
- 2012/2013 to 2020/2021
Methodological detailsmultinational, SWEET Registry, logistic regression adjusted for age at onset and sex, Diabetes diagnosis and classification by each centre per ISPAD definitions
- Multinational
- SWEET Registry
- Logistic regression adjusted for age at onset and sex
- Diabetes diagnosis and classification by each centre per ISPAD definitions
Main finding
As reported in the abstract
Proportion of T2D among new diabetes cases · 2012–2021
Overall new cases with T2D
2819 of 58,170
4.8%
Proportion of T2D, 2012/2013 to 2020/2021
3.2% to 6.0%
Relative rate of increase per two-year period
9%
95% CI 5.9, 12.3p<0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| HbA1c by region · diagnosisEU vs NA · lower with EU · highest in AS/AF, lowest in EU | AS/AF median 85 (IQR 55–111) mmol/mol · HbA1c % 9.9% · EU median 63 (IQR 48–99) mmol/mol · HbA1c % 7.9% · NA median 73 (IQR 50–105) mmol/mol · HbA1c % 8.8% | P = 0.047 |
| BMI SD score by region · diagnosisLowest in AS/AF, highest in AU/NZ | AS/AF median 2.2 (IQR 1.4–2.7) · AU/NZ median 3.1 (IQR 2.5–3.6) |
Proportion of T2D during COVID-19 pandemic · 2020-2021 vs 2018-2019
- Continued to follow observed trend; 2020-2021 vs 2018-2019
- 6.0% vs 5.4%
Proportion of T2D by region
- High variability across regions; lowest in EU, highest in NA
- Significant increase in EU, AU/NZ and NA
Original publication
Frequency and clinical characteristics of children and young people with type 2 diabetes at diagnosis from five world regions between 2012 and 2021: data from the SWEET Registry. Diabetologia. Published 6 November 2024. doi:10.
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