Prevalence and predictive factors of computed tomography-detected pancreatopathy in a cohort of adult patients hospitalized for newly diagnosed or uncontrolled non-auto-immune diabetes
Authors' conclusion
The prevalence of pancreatic lesions in patients hospitalized for diabetes-related glycemic imbalance was significant although malignancy remained low. Age ≥ 65 years, low body mass index, and altered lipid profile may help identify patients requiring pancreatic imaging. Future prospective studies should refine these criteria to develop screening strategies for early pancreatic cancer detection in high-risk selected diabetic populations.
Study context
- Population
- Adults hospitalized for newly diagnosed or uncontrolled DM with a computed tomography (CT) scan within six months of admission, Brest University Hospital, February 2016–February 2022; T1D, prior pancreatectomy or known pancreatic adenocarcinoma excludedanalysed
- Participants
- 412 adults
- Outcome
- Prevalence of pancreatic lesions on CT
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
Pancreatic abnormalities (PA)
53
12.9 %
Malignant pancreatic lesion
11
2.7 %
Observational data: associations, not effects.
Further findings
Predictive factors for PA (P < 0.05)
| OR (95 % CI) | P value | ||
|---|---|---|---|
| Age ≥ 65 years | 2.00 (1.52–5.27) | P < 0.05 | |
| BMI ≤ 26.4 kg/m² | 2.65 (1.1–4.98) | P < 0.05 | |
| LDL/HDL ratio ≤ 3.0 | 4.75 (2.03–11.10) | P < 0.05 | |
| ≥1 clinical warning sign (alcoholic use, steatorrhea, abdominal pain) | 2.29 (1.21–4.33) | P < 0.05 | |
| 0.050.21520Odds ratio (log scale) |
CT scans avoided using all four criteria together
- CT scans avoided, with no missed cases
- 68 of 412
Original publication
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