Complementary value of glycated albumin and continuous glucose monitoring for assessing microvascular complications in type 2 diabetes
Authors' conclusion
In type 2 diabetes, GA is associated with microvascular complications independently of TIR and may provide complementary information when considered alongside TIR.
Study context
- Population
- Individuals with T2D who underwent continuous glucose monitoring (CGM); Diabetic retinopathy (DR) by fundus examination, diabetic kidney disease (DKD) by urinary albumin excretion and/or eGFR
- Participants
- 3,251 individuals
- Exposure
- Highest vs lower glycated albumin (GA) tertiles, adjusted including time in range (TIR)
- Outcome
- DR, DKD and composite microvascular complications (DR and/or DKD), highest GA tertile, adjusted including TIR
Main finding
As reported in the abstract
Estimate (95% CI)
Highest GA tertile
OR (DR) 1.31(1.04–1.64)
Highest GA tertile
OR (DKD) 1.58(1.24–2.02)
Highest GA tertile
OR (composite microvascular complications) 1.44(1.17–1.79)
%
- Median GA
- 20.5 (16.8-25.9)
- Median TIR
- 75.0 (60.0-87.0)
- Participants with microvascular complications
- 45.8
Observational data: associations, not effects.
Further findings
DR, DKD and composite microvascular complications, highest GA tertile, among participants with TIR > 70 %
| Estimate | ||
|---|---|---|
| Highest GA tertile | OR (DR) 1.38 (CI 1.04–1.83) | |
| Highest GA tertile | OR (DKD) 1.95 (CI 1.43–2.65) | |
| Highest GA tertile | OR (composite microvascular complications) 1.57 (CI 1.20–2.05) | |
| 0.20.5125Ratio (log scale) |
Discrimination and reclassification for microvascular complications
- Improvement in net reclassification adding GA to TIR-based models
- 13.2-16.3 %
- GA and TIR showed comparable C-statistics
Original publication
Complementary value of glycated albumin and continuous glucose monitoring for assessing microvascular complications in type 2 diabetes. Diabetes Res Clin Pract. Published 14 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →