Association Between Life's Essential 8 and Diabetic Kidney Disease in Patients With Diabetes Mellitus: Evidence From National Health and Nutrition Examination Survey 2005-2018
Authors' conclusion
LE8 scores were shown to have a significantly negative association with the risk of DKD in people with diabetes mellitus. By concentrating on the state of cardiovascular health, it may be possible to lessen the impact of DKD.
Study context
- Population
- People with DM, National Health and Nutrition Examination Survey 2005–2018
- Exposure
- Higher vs lower Life's Essential 8 score
- Outcome
- DKD
Methodological detailsweighted multivariate logistic regression, restricted cubic spline models, covariate-adjusted, subgroup analyses and interaction tests
- Weighted multivariate logistic regression
- Restricted cubic spline models
- Covariate-adjusted
- Subgroup analyses and interaction tests
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
Per 10-point increase in LE8adjusted for confounders
0.75(0.68–0.84)
P < 0.001High LE8vs Low LE8
0.32(0.15–0.70)
P = 0.005Observational data: associations, not effects.
Further findings
LE8 subscales and diabetic kidney disease (DKD)
- LE8 subscales similarly showed negative associations with DKD risk
Subgroups
- Association between LE8 and DKD consistent across subgroups
Original publication
Association Between Life's Essential 8 and Diabetic Kidney Disease in Patients With Diabetes Mellitus: Evidence From National Health and Nutrition Examination Survey 2005-2018. Endocr Pract. Published 17 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →