V-ATPase subunit C 1 and IKBIP as tandem prospective biomarkers for diabetic nephropathy
Authors' conclusion
The present findings of our study indicate that the decreasing V-ATPase subunit C 1 together with increasing IKBIP in urine, were found to be closely associated with DN complications and signifying their value as biomarkers for predicting the risk of DN at initial diagnosis.
Study context
- Population
- Patients with T2D and controls; urine low-molecular-weight (LMW) proteins assessed as potential predictive markers for DN
- Participants
- 94 vs 32
- Exposure
- T2D patients vs controls
- T2DMn = 94
- Controln = 32reference
- Outcome
- Urinary LMW proteins
Methodological detailsuntargeted LC-MS/MS proteomic profiling
- Untargeted LC-MS/MS proteomic profiling
Main finding
As reported in the abstract
LMW proteins identified and quantified
73
Proteins significantly altered (p < 0.05)
32
Observational data: associations, not effects.
Original publication
V-ATPase subunit C 1 and IKBIP as tandem prospective biomarkers for diabetic nephropathy. Diabetes Res Clin Pract. Published 19 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →