Metabolites as Risk Factors for Diabetic Retinopathy in Patients With Type 2 Diabetes: A 12-Year Follow-up Study
Authors' conclusion
Our study is the first large population-based longitudinal study to identify metabolites for DR. We found multiple metabolites associated with an increased and decreased risk for DR from several different metabolic pathways.
Study context
- Population
- Participants with T2D selected from the METSIM cohort; those with retinopathy before baseline excluded (n = 63); Diabetic retinopathy (DR) diagnosed by fundus photography1,021 without DR, 328 with DR
- Participants
- 1,349 participants
- Outcome
- Metabolites associated with incident DR
- Follow-up
- 12-year follow-up
Methodological details12-year follow-up, nontargeted metabolomics profiling, population-based
- 12-year follow-up
- Nontargeted metabolomics profiling
- Population-based
Main finding
As reported in the abstract
Metabolites associated with incident DR (adjusted for confounders)
- Metabolites significantly associated with incident DR after adjustment
- 17
Observational data: associations, not effects.
Original publication
Metabolites as Risk Factors for Diabetic Retinopathy in Patients With Type 2 Diabetes: A 12-Year Follow-up Study. J Clin Endocrinol Metab. Published 10 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →