Serum MicroRNA-191-5p Levels in Vascular Complications of Type 1 Diabetes: The EURODIAB Prospective Complications Study
Authors' conclusion
In DM1 subjects, microRNA-191-5p is inversely associated with vascular chronic complications of diabetes.
Study context
- Population
- Patients with T1D from the EURODIAB Prospective Complication Study
- Participants
- 420 patients
- Comparison
- Cases with vascular complications vs controls without complications
- Casesn = 277
- Controlsn = 143reference
- Outcome
- Association of serum microRNA-191-5p levels (quantitative PCR) with micro- and macrovascular disease
Methodological detailscross-sectional analysis of the EURODIAB Prospective Complications Study
- Cross-sectional analysis of the EURODIAB Prospective Complications Study
Main finding
As reported in the abstract
microRNA-191-5p and chronic complications, multivariable logistic regression (58% reduced odds)
OR, 0.42; 95% CI, 0.23-0.77
Observational data: associations, not effects.
Further findings
Albuminuria
- microRNA-191-5p and albuminuria, independent association
- OR, 0.36; 95% CI, (0.18-0.75)
Cardiovascular disease (CVD)
- microRNA-191-5p and CVD, independent association
- OR, 0.34; 95% CI, 0.16-0.70
Original publication
Serum MicroRNA-191-5p Levels in Vascular Complications of Type 1 Diabetes: The EURODIAB Prospective Complications Study. J Clin Endocrinol Metab. Published 8 August 2023. doi:10.
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