Metabolomic studies reveal and validate potential biomarkers of diabetic retinopathy in two Chinese datasets with type 2 diabetes: a cross-sectional study
Authors' conclusion
Low levels of circulating L-Tyrosine indicate retinopathy occurrence in T2DM population.
Study context
- Population
- Chinese patients with T2D; discovery dataset 39 diabetic retinopathy (DR) and 39 non-DR (NDR), validation dataset 95 DR and 95 NDRtwo datasets
- Exposure
- DR vs non-DR in T2D
- Outcome
- Serum metabolites as biomarkers for the presence of DR
Methodological detailsuntargeted and targeted metabolomics (liquid chromatography-mass spectrometry (LC-MS), multiple reaction monitoring (MRM)), discovery and validation datasets, risk factor-matched validation set
- Untargeted and targeted metabolomics (LC-MS, MRM)
- Discovery and validation datasets
- Risk factor-matched validation set
Main finding
As reported in the abstract
Serum L-tyrosine (validation set)
DR
−0.22
± 0.87
NDR
0.48
± 1.05
P < 0.001
- L-tyrosine cutoff
- 0.10 mg/ml
- Sensitivity
- 86%
- Specificity
- 40%
- AUC
- 0.62 (95% CI 0.54-0.70; P = 0.005)
Observational data: associations, not effects.
Further findings
Metabolite screening
- Metabolites tested
- 7123
- Serum candidate markers identified
- 9
- Markers associated with DR after covariate adjustment
- 6 of 9
- Eicosapentaenoic acid (EPA) and L-tyrosine validated in independent risk factor-matched set
Original publication
Metabolomic studies reveal and validate potential biomarkers of diabetic retinopathy in two Chinese datasets with type 2 diabetes: a cross-sectional study. Cardiovasc Diabetol. Published 18 December 2024. doi:10.
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