Serum Lipidomics Profiling Identify Novel Biomarkers of Distal Symmetrical Polyneuropathy in Type 1 Diabetes
Authors' conclusion
We identified a reproducible lipidomic signature discriminating DSPN in type 1 diabetes. Painful DSPN was characterized by reduced unsaturated PC/PE and increased sphingolipids, offering new insight into disease pathophysiology.
Study context
- Population
- Individuals with T1D with and without distal symmetrical polyneuropathy (DSPN) and non-diabetic controls (discovery cohort); independent validation cohort of 99 individuals with T1D with established DSPN statusplus validation cohort n=99
- Participants
- 109 / 44 / 50
- Comparison
- T1D with DSPN vs T1D without DSPN vs non-diabetic controls
- T1D with DSPNn = 109
- T1D without DSPNn = 44
- Non-diabetic controlsn = 50reference
- Outcome
- Lipidomic biomarkers of DSPN
Methodological detailsuntargeted serum liquid chromatography-mass spectrometry lipidomics, independent validation cohort
- Untargeted serum liquid chromatography-mass spectrometry lipidomics
- Independent validation cohort
Performance
As reported in the abstract
- Lipid species identified in the discovery cohort
- 543
- Lipids associated with DSPN
- 14
- Lipids with a clear pattern across non-diabetic, T1D without and with DSPN: Cer(d42:1), PC(36:4), LPC(16:0), LPE(18:1), PE(36:2), PE(O-40:5) or PE(P-40:4)
- 6
- Lipids with the same directional changes in the validation cohort (of 6)
- 3
- AUC for detecting DSPN, model of six lipids + HbA1c, diastolic blood pressure and age, discovery cohort
- 0.83 (95% CI, 0.76-0.91)
- AUC for detecting DSPN, same model, validation cohort
- 0.81 (95% CI, 0.73-0.90)
- AUC improvement by DeLong's test, discovery and validation cohorts (not significant)
- p = 0.086 and 0.089
- AUC improvement combined by Fisher's method (significant)
- χ2 = 9.7, p = 0.045
Further findings
- Lipid species differing significantly between painful and painless DSPN
- 22
Original publication
Serum Lipidomics Profiling Identify Novel Biomarkers of Distal Symmetrical Polyneuropathy in Type 1 Diabetes. Diabetes Obes Metab. Published 1 September 2026. doi:10.
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