The Association Between NT ‐Pro BNP , Nephropathy and Endothelial Dysfunction in Patients With Type 2 Diabetes Mellitus
Authors' conclusion
In patients with T2DM without overt heart failure, elevated NT-Pro BNP showed a statistically significant association with lower eGFR and higher albuminuria. Moderate to severe albuminuria becomes an independent factor for elevated NT-Pro BNP after adjustment excluding eGFR. The lack of association with endothelial dysfunction suggests that NT-Pro BNP may reflect different pathophysiological pathways.
Study context
- Population
- Adults with T2D without overt HF
- Participants
- 192 adults
- Exposure
- NT-Pro BNP across KDIGO eGFR groups
- Outcome
- Elevated NT-Pro BNP (≥ 125 pg/mL) and its associations with renal impairment, albuminuria and endothelial dysfunction (FMD)
Methodological detailscomparative
- Comparative
Main finding
As reported in the abstract
NT-Pro BNP level
P < 0001
- Correlation of NT-Pro BNP with urinary albumin-to-creatinine ratio (uACR) (r)
- 0.31, p < 0.001
- No significant association between NT-Pro BNP and flow-mediated dilatation (FMD)
- P = 0.388
- Older age, independent factor for elevated NT-Pro BNP (aOR)
- 1.14, 95% CI: 1.06-1.23, p < 0.001
- Higher systolic BP, independent factor (aOR)
- 1.05, 95% CI: 1.02-1.08, p = 0.010
- Lower eGFR, independent factor (aOR)
- 0.97, 95% CI: 0.95-0.99, p = 0.003
- Beta-blocker use, independent factor (aOR)
- 4.65, 95% CI: 1.61-13.45, p < 0.001
Observational data: associations, not effects.
Original publication
The Association Between NT ‐Pro BNP , Nephropathy and Endothelial Dysfunction in Patients With Type 2 Diabetes Mellitus. Diabetes Obes Metab. Published 1 September 2026. doi:10.
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