Epicardial adipose tissue volume and nephropathy in people living with type 2 diabetes: the Kidn-EAT study
Main findingResult — go to the resultOdds ratio 1.058 95% CI 1.007–1.112Authors' conclusion
EAT volume was associated with nephropathy and especially with increased ACR in PwT2D.
Study context
- Population
- PwT2D with CT measuring coronary artery calcium score and epicardial adipose tissue (EAT) volume, and available estimated glomerular filtration rate (eGFR) and albuminuria/creatininuria ratio (ACR); 332 women, mean age 60.3 ± 10.4 years, 44.8% with obesity332 women
- Participants
- 700 participants
- Exposure
- Nephropathy vs no nephropathy
- Nephropathyn = 295
- Outcome
- Association between EAT volume and presence of nephropathy and its components (ACR and eGFR classes)
Methodological detailscross-sectional analysis of a retrospective cohort
- Cross-sectional analysis of a retrospective cohort
Main finding
As reported in the abstract
Odds ratio
1.058
95% CI 1.007–1.112
P = 0.026
By group
Each 10 cm³ increase of EAT volume
OR 1.058 (95% CI 1.007–1.112); P = 0.026
Each 10 cm³ increase of EAT volume, as printed
Observational data: associations, not effects.
Further findings
| Outcome | Values | OR (95% CI) | P value | |
|---|---|---|---|---|
| ACR ≥ 3 mg/mmol per 10 cm³ increase of EAT volume (adjusted)Adjusted for major confounding factors | 1.059 (1.008–1.114) | P = 0.024 | ||
| eGFR < 60 mL/min/1.73m2 per 10 cm³ increase of EAT volume (adjusted)Adjusted for major confounding factors | 1.047 (0.975–1.123) | P = 0.204 | ||
| 0.512Odds ratio (log scale) |
| Outcome | Values | P value |
|---|---|---|
| EAT volume by eGFR classeGFR < 60 vs eGFR ≥ 60 | eGFR ≥ 60 mean 96.6 (SD 38.1) · eGFR < 60 mean 107.7 (SD 39.2) | P = 0.012 |
| EAT volume by ACR class | ACR < 3 mean 94.7 (SD 36.9) cm³ · ACR 3–29.9 mean 106.0 (SD 40.2) cm³ · ACR ≥ 30 mean 95.7 (SD 39.8) cm³ | P = 0.004 |
Nephropathy components prevalence
- Nephropathy
- 295 (42.1%)
- eGFR < 60 ml/min/1.73m2
- 87 (12.4%)
- ACR ≥ 3 mg/mmol
- 258 (36.9%)
Correlation of EAT volume with eGFR and ACR
- Correlation with eGFR (r)
- r = −0.146; p < 0.001
- Correlation with ACR (r)
- r = 0.124; p = 0.001
- Weak correlations
Original publication
Epicardial adipose tissue volume and nephropathy in people living with type 2 diabetes: the Kidn-EAT study. Cardiovasc Diabetol. Published 30 July 2026. doi:10.
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