Epicardial adipose tissue volume and arterial stiffness in people living with diabetes: the METAB-CV-PWV study
Authors' conclusion
EAT volume was associated with arterial stiffness in people living with diabetes. This association suggests that systemic inflammatory and metabolic mechanisms, through EAT and/or other associated ectopic adipose tissues, may contribute to an increased risk of cardiovascular disease.
Study context
- Population
- People living with diabetes with CT (coronary artery calcium score and epicardial adipose tissue (EAT) volume) and finger-to-toe pulse wave velocity (PWV); 198 men, mean age 55.6 ± 12.6 years, 73.6% T2D, 41.6% obesity, median diabetes duration 12 (IQR 6–20) years
- Participants
- 345 people
- Exposure
- EAT volume across PWV tertiles
- Outcome
- Correlation between EAT volume and PWV
Methodological detailspart retrospective, part prospective, non-interventional
- Part retrospective, part prospective
- Non-interventional
Main finding
As reported in the abstract
Positive correlation, EAT volume vs PWV: r (95%CI 0.27-0.45), p < 0.001
0.37
Median PWV, m/sec (IQR 7.0-10.0)
8.0
Median EAT volume, cm³ (IQR 61.8-114.3)
84.9
Observational data: associations, not effects.
Further findings
EAT volume by PWV tertile — between First PWV tertile and Third PWV tertile · across the three tertiles
P < 0.001 for all three
Third PWV tertile per 10 cm³ increase in EAT volume
- OR (95%CI 1.06 - 1.21; p < 0.001), adjusted for age, mean blood pressure, BMI and diabetes type
- 1.14
- 14% increase in probability per 10 cm³
Original publication
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