Epicardial adipose tissue volume and diabetic retinopathy
Main finding · EAT volumeResult — go to the resultOdds ratio 0.89 95 % CI 0.84–0.93Authors' conclusion
We found an unexpected negative association between the volume of EAT-a proinflammatory tissue-and diabetic retinopathy prevalence. This finding warrants further mechanistic investigation.
Study context
- Population
- Individuals living with diabetes with a computed tomography (CT) scan for coronary artery calcium (CAC) score and known DR status (T2D 79.1 %, T1D 14.8 %, other 6.2 %); diabetes duration 14.6 ± 9.9 years; BMI 29.4 ± 5.9 kg/m², HbA1c 8.7 ± 2.2 %
- Participants
- 1,037 individuals
- Exposure
- DR vs no DR
- Outcome
- Association between EAT volume and DR
Methodological detailsmonocentric
- Monocentric
Main finding
EAT volume
Odds ratio
0.89
95 % CI 0.84–0.93
P < 0.0001
By group
EAT volume per 10cm3 increase
OR 0.89 (95 % CI 0.84–0.93); P < 0.0001
Per 10cm3 increase, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
Prevalence of DR and mean epicardial adipose tissue (EAT) volume
- Had DR
- 38.2 %
- EAT volume
- 93 ± 40 cm³
Factors associated with DR
- DR positively associated with North African ethnicity, T1D, longer diabetes duration, higher HbA1c, and more hypertension and diabetes-related complications (nephropathy, neuropathy, macroangiopathy, high CAC score)
Original publication
Epicardial adipose tissue volume and diabetic retinopathy. Diabetes Metab. Published 8 October 2025. doi:10.
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