Nonglycemic and Glycemic Risk Factors for Painful Neuropathic Symptoms and for Distal Symmetrical Polyneuropathy (DSPN) in the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study
Authors' conclusion
In this cohort, risk factors for painful neuropathic symptoms and DSPN differed. Improved recognition of painful neuropathic symptoms and better consensus on diagnostic criteria may facilitate research into their causes, prevention, and treatment.
Study context
- Population
- DPP/DPPOS participants assessed ∼21 years after DPP randomization; symptoms by Michigan Neuropathy Screening Instrument (MNSI) questionnaire, signs by pinprick, vibration and monofilament testing
- Participants
- 1,779 participants
- Exposure
- Risk factors across neuropathy phenotypes: painful neuropathic symptoms and DSPN vs no symptoms or signs
- No symptoms or signsn = 501reference
- Neuropathic pain without signsn = 144
- DSPNn = 473
- Outcome
- Nonglycemic and glycemic risk factors associated with painful neuropathic symptoms and DSPN
- Follow-up
- ∼21 years after DPP randomization
Methodological detailsDPP/DPPOS participants, multinomial logistic regression
- DPP/DPPOS participants
- Multinomial logistic regression
Main finding
As reported in the abstract
Neuropathy phenotype prevalence and risk factors
Observational data: associations, not effects.
Original publication
Nonglycemic and Glycemic Risk Factors for Painful Neuropathic Symptoms and for Distal Symmetrical Polyneuropathy (DSPN) in the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study. Diabetes Care. Published 18 June 2025. doi:10.
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