Distal symmetrical polyneuropathy in prediabetes is associated with abdominal obesity and insulin resistance
Authors' conclusion
The prevalence of DSPN in prediabetes is not negligible in our study. DSPN is independently associated with central obesity and insulin resistance.
Study context
- Population
- Consecutive adults with prediabetes attending the Outpatient Lipid and Obesity Clinic, University Hospital of Ioannina, Greece
- Participants
- 160 adults
- Exposure
- Distal symmetrical polyneuropathy (DSPN) vs no DSPN
- DSPNn = 27
- Outcome
- Prevalence of DSPN in prediabetes
Methodological detailscross-sectional analysis of baseline data of a prospective observational study, consecutive recruitment, single-centre
- Cross-sectional analysis of baseline data of a prospective observational study
- Consecutive recruitment
- Single-centre
Main finding
As reported in the abstract
Prevalence of DSPN
DSPN
16.9%
27
Observational data: associations, not effects.
Further findings
Factors independently associated with prevalent DSPN (multivariate analysis)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Waist circumference | 1.092 (1.037–1.148) | P < 0.001 | |
| HOMA-IR | 1.247 (1.095–1.425) | P = 0.004 | |
| 0.512Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Factors independently linked with prevalent DSPN (sensitivity analysis)Current/previous smokingvs Never-smokingSensitivity analysis | 1.347 (1.116–1.891) | P = 0.042 | |
| 0.512Odds ratio (log scale) |
Factors independently linked with prevalent DSPN (sensitivity analysis)
| OR (95% CI) | P value | ||
|---|---|---|---|
| HeightSensitivity analysis | 1.083 (1.004–1.168) | P = 0.039 | |
| 0.512Odds ratio (log scale) |
PWV
P = 0.031
Abnormal PWV (≥10 m/s)
P = 0.029
Association of pulse wave velocity (PWV) with VPT
- PWV independently associated with VPT
- beta 1.010 (95% CI 0.123-1.897, p = 0.026)
Original publication
Distal symmetrical polyneuropathy in prediabetes is associated with abdominal obesity and insulin resistance. Diabetes Res Clin Pract. Published 4 February 2026. doi:10.
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