Prevalence of Distal Symmetrical Polyneuropathy by Diabetes Prevention Program Treatment Group, Diabetes Status, Duration of Diabetes, and Cumulative Glycemic Exposure
Authors' conclusion
The likelihood of DSPN was similar across DPP treatment groups but higher for those with diabetes, longer diabetes duration, and higher cumulative glycemic exposure. ILS may have long-term benefits on DSPN for older adults.
Study context
- Population
- Adults ≥25 years at high risk for diabetes randomised in the DPP, followed in DPPOS; Distal symmetric polyneuropathy (DSPN) assessed at DPPOS year 17 (≈21 years after randomisation)3,234 randomized
- Participants
- 1,792 adults
- Comparison
- Intensive lifestyle (ILS) vs metformin vs placebo
- Primary endpoint
- DSPN prevalence
- Follow-up
- DPPOS year 17 (≈21 years after DPP randomization)
Methodological detailslong-term follow-up, multivariable logistic regression, 2,779 joined DPPOS; open-label metformin continued, placebo discontinued, ILS as semiannual group classes, quarterly lifestyle classes offered to all
- Long-term follow-up
- Multivariable logistic regression
- 2,779 joined DPPOS; open-label metformin continued, placebo discontinued, ILS as semiannual group classes, quarterly lifestyle classes offered to all
Primary result
As reported in the abstract
21 years after DPP randomization
Further findings
DSPN prevalence by diabetes status
| Outcome | OR for DSPN, lower per 5-year age interval (95% CI) | P value |
|---|---|---|
| Interaction of ILS assignment and age on DSPN · DPPOS year 17ILS vs Placebo · lower with increasing 5-year age intervals | 17.4% (3.0–29.3) | P < 0.05 for interaction |
- DSPN prevalence by diabetes status — DSPN associated with longer diabetes duration and time-weighted HbA1c
- P values <0.001
Diabetes prevalence · 21 years after DPP randomization
- Subjects with diabetes
- 66%
Original publication
Prevalence of Distal Symmetrical Polyneuropathy by Diabetes Prevention Program Treatment Group, Diabetes Status, Duration of Diabetes, and Cumulative Glycemic Exposure. Diabetes Care. Published 19 March 2024. doi:10.
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