Plasma Ceramides and Other Sphingolipids in Relation to Incident Prediabetes in a Longitudinal Biracial Cohort
Authors' conclusion
We conclude that the saturated-to-monounsaturated ratios of long-chain ceramide C18:0/C18:1 and very-long-chain sphingomyelin C26:0/C26:1 are potential biomarkers of prediabetes risk among individuals with parental history of type 2 diabetes.
Study context
- Population
- Normoglycemic adults in the Pathobiology of Prediabetes in a Biracial Cohort study; 50% Black, 50% female; mean age 48.1 ± 8.69 years, BMI 30.1 ± 5.78 kg/m²58 sphingolipid species assayed
- Participants
- 140 adults
- Comparison
- Baseline plasma sphingolipid ratios vs progression to prediabetes
- Outcome
- Progression from normoglycemia to prediabetes (impaired fasting glucose or impaired glucose tolerance)
- Follow-up
- 5-year follow-up
Methodological detailsnested in the Pathobiology of Prediabetes in a Biracial Cohort study, 5-year follow-up, matched on age, sex and ethnicity, single academic health center
- Nested in the Pathobiology of Prediabetes in a Biracial Cohort study
- 5-year follow-up
- Matched on age, sex and ethnicity
- Single academic health center
Main finding
As reported in the abstract
Progression to prediabetes by baseline sphingolipid ratios
Odds ratio (95% CI)P value
Higher sphingomyelin C26:0/C26:1 ratio
2.73(1.172–4.408)
P = 0.015Higher ceramide C18:0/C18:1 ratio
1.236(1.042–1.466)
P = 0.015Observational data: associations, not effects.
Original publication
Plasma Ceramides and Other Sphingolipids in Relation to Incident Prediabetes in a Longitudinal Biracial Cohort. J Clin Endocrinol Metab. Published 19 March 2024. doi:10.
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