Plasma Sphingolipids in Relation to Glycemia and Glucose Tolerance in People Without Diabetes
Authors' conclusion
Circulating levels of major sphingolipid species are significantly associated with glycemia and glucose tolerance, indicating a possible link between sphingolipid metabolism and glucoregulation in people without diabetes.
Study context
- Population
- Adults without diabetes from the Pathobiology of Prediabetes in a Biracial Cohort study and the Diabetes Prevention Program; 63% female, 48% Black, mean age 45.5 ± 9.84 years, body mass index (BMI) 32.4 ± 7.24 kg/m²Diabetes Prevention Program 280
- Exposure
- Plasma sphingolipids across glucose tolerance categories
- Outcome
- Association of plasma sphingolipids with FPG, 2hPG and glucose tolerance category
- Follow-up
- Baseline
Methodological detailsbaseline specimens from two cohorts (POP-ABC and DPP), liquid chromatography tandem mass spectrometry
- Baseline specimens from two cohorts (POP-ABC and DPP)
- Liquid chromatography tandem mass spectrometry
Main finding
As reported in the abstract
Ceramides, sphingomyelins and sphingosine increased progressively across NFG-NGT, isolated impaired glucose tolerance (IGT) and IFG-IGT; the opposite for monohexosyl ceramides, lactosyl ceramides and sphingosine-1 phosphate
ANOVA P < .0001
Observational data: associations, not effects.
Original publication
Plasma Sphingolipids in Relation to Glycemia and Glucose Tolerance in People Without Diabetes. J Clin Endocrinol Metab. Published 26 June 2025. doi:10.
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