Blood glucose and body weight reduction for the prevention of clinical events and mortality in patients with type 2 diabetes: A meta‐analysis and meta‐regression of 44 randomized controlled trials
Pooled result · All-cause mortalityResult — go to the resultHazard ratio 0.93 95% CI 0.89–0.96Authors' conclusion
Reductions in body weight and HbA1c may play a significant role in preventing the risk of major adverse cardiovascular event (MACE) events and mortality.
Study context
- Population
- Patients with T2D in large-scale RCTs of glucose-lowering therapies (MEDLINE, CENTRAL, EMBASE through March 31, 2025)
- Participants
- 274,800 patients44 RCTs
- Comparison
- Glucose-lowering therapies vs placebo or active control
- Outcome
- All-cause mortality
Methodological detailsrandom-effects meta-regression, univariate and adjusted meta-regression
- Random-effects meta-regression
- Univariate and adjusted meta-regression
Pooled result
As reported in the abstract
Hazard ratio
0.93
95% CI 0.89–0.96
P < 0.0001
Glucose-lowering therapiesvs Placebo or active control
HR 0.93 (95% CI 0.89–0.96); P < 0.0001
- Heterogeneity across drug classes
- P for interaction = 0.0006
Further pooled results
All-cause mortality per 1-kg difference in body weight (univariate meta-regression)
- Difference in HR of all-cause mortality per 1-kg body weight difference
- 3.1% (1.4% - 4.9%); p = 0.0003
- Univariate meta-regression
All-cause mortality per 1-kg body weight reduction, adjusted for HbA1c reduction
- Risk reduction in all-cause mortality per 1-kg body weight reduction
- 3.4% (1.8% - 5.1%; p < 0.0001)
- Adjusted for reduction in HbA1c
All-cause mortality per 1% HbA1c reduction, irrespective of body weight reduction
- Risk reduction in all-cause mortality per 1% HbA1c reduction
- 7.6% (0.9% - 14.8%; p = 0.0246)
Original publication
Blood glucose and body weight reduction for the prevention of clinical events and mortality in patients with type 2 diabetes: A meta‐analysis and meta‐regression of 44 randomized controlled trials. Diabetes Obes Metab. Published 25 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →