Renal function and its association with retinal microcirculation and choroidal thickness in type 2 diabetes: Insights from cystatin C and creatinine
Authors' conclusion
Retinal microcirculation changes in T2DM reflect renal dysfunction. These findings suggest its potential role in detecting early renal impairment, particularly in the absence of DR.
Study context
- Population
- Patients with T2D undergoing SS-OCTA and SS-OCT; renal function by eGFR from cystatin C and creatinine (eGFRcr-cys)
- Participants
- 1,050 patients
- Outcome
- Association of eGFRcr-cys with superficial (SCP) and deep (DCP) capillary plexus vessel densities and macular choroidal thickness (mCT)
Main finding
As reported in the abstract
- eGFRcr-cys vs SCP-VD, β (positive)
- 0.62
- eGFRcr-cys vs mCT, β (positive)
- 5.55
- eGFRcr-cys vs DCP-VD, β (negative)
- −0.69
- All associations P
- P < 0.05
Observational data: associations, not effects.
Further findings
Sensitivity analyses incorporating uric acid
- Associations remained robust in sensitivity analyses
Stratified by diabetic retinopathy (DR): non-DR patients
- eGFRcr-cys positively associated with SCP-VD and negatively with DCP-VD
Stratified by DR: DR patients
- eGFRcr-cys positively associated with both SCP-VD and mCT
Original publication
Renal function and its association with retinal microcirculation and choroidal thickness in type 2 diabetes: Insights from cystatin C and creatinine. Diabetes Res Clin Pract. Published 25 June 2025. doi:10.
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