Global burden of diabetes in reproductive-age women (1990–2021), with projections to 2045: Systematic analysis of the global burden of disease study 2021
Authors' conclusion
The diabetes burden among RAW has increased alarmingly over the past 30 years and is projected to continue rising over the next two decades, underscoring the urgent need for decisive intervention.
Study context
- Population
- Reproductive-age women (RAW) worldwide, 1990–2021, GBD 2021 data
- Outcome
- Diabetes burden among RAW
- Follow-up
- 2021; projection to 2045
Methodological detailsBayesian age-period-cohort projections to 2045, stratified by region, age group and Socio-demographic Index (SDI)
- Bayesian age-period-cohort projections to 2045
- Stratified by region, age group and SDI
Main finding
As reported in the abstract
RAW affected by diabetes worldwide, 2021
79.04 million
Projected RAW affected by diabetes, 2045
221.17 million
Projected surge 2021 to 2045
2.8-fold
Observational data: associations, not effects.
Further findings
Age patterns by diabetes type
- T2DM burden escalates with age, with faster incidence rate growth in younger cohorts
- T1DM prevalence peak shifts toward older ages; incidence declines with advancing age
Risk factors
%
- High BMI, leading risk factor for T2DM: share of deaths
- 62.88
- High BMI, leading risk factor for T2DM: share of DALYs
- 62.45
- Non-optimal temperature affects T1DM; climate change exacerbates heat-related risks for both types
Original publication
Global burden of diabetes in reproductive-age women (1990–2021), with projections to 2045: Systematic analysis of the global burden of disease study 2021. Diabetes Res Clin Pract. Published 25 June 2025. doi:10.
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