Incidence and predictors of distal symmetrical polyneuropathy in prediabetes: A 24-month prospective cohort study
Authors' conclusion
We observed a 9.8% 24-month incidence of DSPN in people with prediabetes. Age, male sex, smoking, central obesity, as well as insulin resistance at baseline and change over time were independent predictors of incident DSPN.
Study context
- Population
- Adults with prediabetes attending the Outpatient Lipid and Obesity Clinic, University Hospital of Ioannina, Greece133 without distal symmetrical polyneuropathy (DSPN) at baseline
- Participants
- 160 adults
- Outcome
- Incidence of DSPN (assessed by neuropathy symptom score (NSS), neuropathy disability score (NDS) and vibration perception threshold (VPT))
- Follow-up
- Median 24 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Incident DSPN · 24 months (IQR 20-27)
Developed DSPN among 133 participants without baseline DSPN
13
Incidence of DSPN
9.8%
Observational data: associations, not effects.
Further findings
DSPN at baseline
- DSPN at baseline
- 27 (16.9%)
Independent predictors of incident DSPN (multivariable analysis)
- Age, OR per 1-year increase
- 1.11 (1.02-1.24) (95% CI)
- Male sex, OR
- 1.07 (1.01-3.28) (95% CI)
- Current/previous smoking, OR
- 1.17 (1.07-3.03) (95% CI)
- Waist circumference, OR per 1-cm increase
- 1.04 (1.02-1.28) (95% CI)
- Homeostatic model assessment of insulin resistance (HOMA-IR), OR per 0.1-increase
- 1.83 (1.03-2.46) (95% CI)
- ΔHOMA-IR, OR per 0.1 increase
- 1.46 (1.07-2.46) (95% CI)
- All p < 0.05
Original publication
Incidence and predictors of distal symmetrical polyneuropathy in prediabetes: A 24-month prospective cohort study. Diabetes Res Clin Pract. Published 13 August 2026. doi:10.
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