Fructosamine as a predictor of incident diabetic microvascular disease in a population with high prevalence of red cell disorders: A cohort study
Authors' conclusion
In this patient population, a single measurement of fructosamine significantly and independently predicts incident retinopathy in individuals with HbA1c < 7.0% (53 mmol/mol). Routine measurement of fructosamine on at least one occasion is recommended as part of assessment of prediabetes or diabetes mellitus in populations with a high prevalence of conditions affecting erythrocyte lifespan.
Study context
- Population
- Individuals with prediabetes, T1D or T2D in whom HbA1c was suspected unreliable by their primary physician, in a population with high prevalence of conditions affecting erythrocyte survival (variant haemoglobin, G6PD deficiency)
- Participants
- 60 / 161 / 1,350
- Exposure
- Fructosamine thresholds (≥250 and ≥300 umol/L) as predictors of incident retinopathy and microalbuminuria
- Prediabetesn = 60
- Type 1n = 161
- Type 2 diabetesn = 1,350
- Outcome
- Incident retinopathy and albuminuria
- Follow-up
- 4.4 ± 2.3 years
Main finding
As reported in the abstract
- Fructosamine ≥ 250 umol/L significantly associated with incident retinopathy, in univariate analysis and adjusted for established risk factors
- Fructosamine ≥ 300 umol/L significantly associated with incident microalbuminuria, in univariate analysis and adjusted for established risk factors
Observational data: associations, not effects.
Further findings
Incident retinopathy in individuals with HbA1c < 7.0% (53 mmol/mol) at inclusion
- Fructosamine ≥ 250 umol/L significantly associated with incident retinopathy
Original publication
Fructosamine as a predictor of incident diabetic microvascular disease in a population with high prevalence of red cell disorders: A cohort study. Diabetes Res Clin Pract. Published 12 August 2023. doi:10.
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