Modifiable kidney disease risk factors among nondiabetic adults with obesity from the Multi‐Ethnic Study of Atherosclerosis
Authors' conclusion
Slow walking pace and weight gain were associated with CKD risk among adults with obesity who did not have diabetes at baseline.
Study context
- Population
- Nondiabetic adults with obesity without baseline chronic kidney disease (CKD), Multi-Ethnic Study of Atherosclerosis (MESA); median BMI 33.0 kg/m² (IQR 31.2–35.9)
- Participants
- 1,208 adults
- Exposure
- Weight change and slow walking pace (<2 miles/h) as exposures for estimated glomerular filtration rate (eGFR) decline and incident CKD
- Outcome
- (i) Rate of annual eGFR decline and (ii) incident CKD (eGFRCr-Cys < 60 mL/min/1.73 m²)
Methodological detailslinear mixed-effects and multistate models, adjusted for demographics, time-varying covariates including blood pressure, and comorbidities
- Linear mixed-effects and multistate models
- Adjusted for demographics, time-varying covariates including blood pressure, and comorbidities
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)
Slow walking paceCKD risk
1.48(1.08–2.01)
Weight gainCKD risk per 5 kg weight gain from baseline
1.34(1.02–1.78)
Per 5 kg weight gain from baseline, as printed
- Slow walking pace
- eGFR decline −0.27 mL/min/1.73 m² /year (95% CI −0.42 to −0.12)
- Developed CKD
- 15%
Observational data: associations, not effects.
Original publication
Modifiable kidney disease risk factors among nondiabetic adults with obesity from the Multi‐Ethnic Study of Atherosclerosis. Obesity (Silver Spring). Published 28 September 2023. doi:10.
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