Association of Eicosanoids and Eicosanoid‐Related Metabolites With Obesity and Cardiometabolic Traits
Authors' conclusion
We identified 82 BMI-associated eicosanoids, including docosanoids and arachidonic acid derivatives associated with lower BMI, while octadecanoids and adrenic acid derivatives were associated with higher BMI.
Study context
- Population
- Multi-Ethnic Study of Atherosclerosis (MESA) participants (mean age 63 years, 53% women); external validation in Framingham Heart Study and Atherosclerosis Risk in Communities StudyMESA
- Participants
- 5,101 participants
- Outcome
- Association of 811 eicosanoids with BMI and eight related adiposity and cardiometabolic traits
Methodological detailsexternal validation in two community-based cohorts, multivariable-adjusted linear regression
- External validation in two community-based cohorts
- Multivariable-adjusted linear regression
Main finding
As reported in the abstract
- Eicosanoids and related metabolites associated with BMI in MESA (FDR q < 0.01 for all)
- 255
- Showed consistent associations across all three cohorts
- 82
- Metabolites with known identities among the consistent associations
- 18
- Known metabolites associated with lower BMI, incl. docosahexaenoic acid derivative, arachidonic acid derivatives and eicosapentaenoic acid derivative 5-HpEPE
- 9
- Known metabolites associated with higher BMI, incl. HOME, 11-HOME and adrenic acid
- 9
Observational data: associations, not effects.
Further findings
BMI-associated metabolites overlapping with other adipose traits
- Overlap with waist circumference
- 240 (94%)
- Overlap with visceral adipose tissue
- 93 (36%)
Original publication
Association of Eicosanoids and Eicosanoid‐Related Metabolites With Obesity and Cardiometabolic Traits. Diabetes Obes Metab. Published 1 September 2026. doi:10.
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