Suppression of Endogenous Insulin Secretion by Euglycemic Hyperinsulinemia
Authors' conclusion
Hyperinsulinemia suppresses endogenous insulin secretion and the relative change in insulin secretion produced by exogenous insulin did not differ between nonobese and obese people.
Study context
- Population
- Volunteers, nonobese and obese, undergoing euglycemic hyperinsulinemic clamp (target plasma glucose 95 mg/dL)
- Participants
- 52 volunteers
- Comparison
- Nonobese vs obese volunteers
- Outcome
- Percent change in ISR from fasting to end of insulin clamp
- Follow-up
- End of insulin clamp interval
Methodological detailseuglycemic hyperinsulinemic clamp, 2-step and single-step insulin clamp studies
- Euglycemic hyperinsulinemic clamp
- 2-step and single-step insulin clamp studies
Main finding
As reported in the abstract
Percent change in ISR, fasting to end of clamp
Suppression of ISR from baseline to end of clamp (SD 20)
27%
Further findings
| Outcome | P value |
|---|---|
| ISR under fasting and clamp conditionsISR greater in obese | P < 0.001 |
Correlation of change in plasma glucose with change in ISR · baseline to end of clamp
- R (P < .001)
- 0.61
ISR suppression, second vs first step of 2-step clamp
- Greater suppression of ISR during second step than first step (P < .001)
Original publication
Suppression of Endogenous Insulin Secretion by Euglycemic Hyperinsulinemia. J Clin Endocrinol Metab. Published 27 September 2023. doi:10.
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