Epigenome-Wide Meta-analysis Reveals Associations Between Dietary Glycemic Index and Glycemic Load and DNA Methylation in Children and Adolescents of Different Body Sizes
Authors' conclusion
We identified 537 associations between dietary GI and GL and blood DNAm, mainly in children and adolescents with overweight or obesity. High-GI and/or -GL diets may influence epigenetic gene regulation and thereby promote metabolic derangements in young people with increased BMI.
Study context
- Population
- Children and adolescents aged 4.5–17 years from six cohorts
- Participants
- 1,187 children6 cohorts
- Comparison
- Dietary glycemic index (GI) and glycemic load (GL) vs blood DNA methylation
- Normal weightn = 801
- Overweight or obesityn = 386
- Outcome
- Association of dietary GI and GL with blood DNA methylation (CpG sites, FDR <0.05)
Methodological detailsmeta-analysis of six cohorts, stratified by weight status, gene expression look-ups
- Meta-analysis of six cohorts
- Stratified by weight status
- Gene expression look-ups
Pooled result
As reported in the abstract
CpGs associated with dietary GI/GL (FDR <0.05)
- Dietary GL positively associated with DNA methylation (DNAm) of cg20274553 (annotated to WDR27), overall
- FDR <0.05
- Normal weight: Cytosine-phosphate-guanine (CpGs) identified for GI
- 85
- Normal weight: CpGs identified for GL
- 17
- Overweight or obesity: CpGs identified for GI
- 136
- Overweight or obesity: CpGs identified for GL
- 298
- CpGs overlapping between strata
- 0
Further pooled results
Gene expression look-ups in overweight or obesity
- Identified CpGs related to RNA expression of genes associated with impaired metabolism (e.g., FRAT1, CSF3)
Original publication
Epigenome-Wide Meta-analysis Reveals Associations Between Dietary Glycemic Index and Glycemic Load and DNA Methylation in Children and Adolescents of Different Body Sizes. Diabetes Care. Published 26 September 2023. doi:10.
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