Visceral adipocyte size links obesity with dysmetabolism more than fibrosis, and both can be estimated by circulating miRNAs
Authors' conclusion
These findings suggest that VAT adipocyte size and fibrosis are inversely correlated in obesity and can be estimated by distinct circ-miRNAs, providing a potential tool to subphenotype obesity via a liquid biopsy-like approach to assess VAT health in nonsurgical patients.
Study context
- Population
- Participants with obesity (BMI ≥ 30 kg/m²)
- Participants
- 43 participants
- Exposure
- Above- vs below-median visceral adipose tissue (VAT) adipocyte area; circ-miRNA panels for VAT adipocyte size and fibrosis
- Outcome
- VAT adipocyte size vs metabolic dysfunction and fibrosis
Methodological detailsmatched-pairs subanalyses
- Matched-pairs subanalyses
Main finding
As reported in the abstract
miRNA-130b-3p + miR-150-5p + HDL-C discriminating large vs small VAT adipocytes, AUC
0.872
95% CI 0.747–0.996
miRNA-130b-3p + miRNA-15a-5p + HDL-C discriminating low vs high fibrosis, AUC
0.823
95% CI 0.676–0.97
Observational data: associations, not effects.
Further findings
Circ-miRNAs associated with VAT adipocyte size and fibrosis (Next Generation Sequencing)
- Circ-miRNAs associated with VAT adipocyte size
- 22
- Circ-miRNAs associated with VAT fibrosis
- 6
- miRNA-130b-3p common to both analyses
Original publication
Visceral adipocyte size links obesity with dysmetabolism more than fibrosis, and both can be estimated by circulating miRNAs. Obesity (Silver Spring). Published 25 September 2023. doi:10.
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