Predictive Performance of Seven Clinical Surrogates of Visceral Adipose Tissue for Cardiovascular Mortality: A Sub‐Analysis of 102 385 Adults From the Mexico City Prospective Study
Authors' conclusion
In this large cohort of Mexican adults, four VAT-related clinical surrogates, particularly METS-VF, showed good discriminatory performance for long-term CVD mortality.
Study context
- Population
- Adults without diabetes, Mexico City Prospective Cohort (baseline 1998–2004); median age 47 years, 67% femalewithout diabetes
- Participants
- 102,385 adults
- Exposure
- Seven visceral adipose tissue (VAT)-related clinical surrogates for predicting cardiovascular disease (CVD) mortality
- Outcome
- CVD mortality (cardiac, stroke-related and other vascular causes)
- Follow-up
- Median 20.13 years
Methodological detailspopulation-based, sub-analysis
- Population-based
- Sub-analysis
Main finding
As reported in the abstract
CVD mortality per 1-SD increase in surrogate · median 20.13 years
| Group | Harrell's C-statistic | aHR | 95% CI | CI |
|---|---|---|---|---|
| METS-VF | 0.73 | 1.23 | 1.18-1.29 | |
| EVA | 0.73 | 1.19 | 1.15-1.24 | |
| CVAI | 0.71 | 1.19 | 1.15-1.23 | |
| DAAT | 0.63 | 1.18 | 1.14-1.23 |
Harrell's C-statistic
METS-VF0.73
EVA0.73
CVAI0.71
DAAT0.63
aHR
METS-VF1.23
EVA1.19
CVAI1.19
DAAT1.18
95% CI
METS-VF1.18-1.29
EVA— not stated in the abstract
CVAI— not stated in the abstract
DAAT— not stated in the abstract
CI
METS-VF— not stated in the abstract
EVA1.15-1.24
CVAI1.15-1.23
DAAT1.14-1.23
- Deaths from any CVD cause
- 4068 (3.97%)
Observational data: associations, not effects.
Further findings
Adding METS-VF to Globorisk score in intermediate-risk individuals
- Slightly improved discrimination for CVD mortality
Original publication
Predictive Performance of Seven Clinical Surrogates of Visceral Adipose Tissue for Cardiovascular Mortality: A Sub‐Analysis of 102 385 Adults From the Mexico City Prospective Study. Diabetes Obes Metab. Published 21 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →