DNA Methylation at ABCG1 and Long-term Changes in Adiposity and Fat Distribution in Response to Dietary Interventions: The POUNDS Lost Trial
Authors' conclusion
Baseline DNA methylation at ABCG1 interacted with dietary protein intake on long-term decreases in adiposity and body fat distribution. Participants with lower methylation at ABCG1 benefitted more in long-term reductions in body weight, waist circumference, and body fat distribution when consuming an average-protein diet.
Study context
- Population
- Overweight/obese participants from the POUNDS Lost trial; blood regional DNA methylation at ABCG1 profiled at baseline by methylC-capture sequencing543 followed at 2 years
- Participants
- 673 participants
- Comparison
- Interaction of baseline ABCG1 DNA methylation with average-protein (15%) vs high-protein (25%) diet
- Primary endpoint
- Changes in adiposity (body weight, waist circumference) and CT-measured body fat distribution
- Follow-up
- 6 months and 2 years
Primary result
As reported in the abstract
- Average-protein diet: lower baseline ABCG1 methylation associated with greater reductions in body weight and waist circumference
- High-protein diet: opposite associations
- Average-protein (15%) vs High-protein (25%): interaction P < 0.05 for all
Further findings
| Outcome | P value |
|---|---|
| CT-measured body fat distribution (VAT, SAT, deep SAT, total adipose tissue) · 6 months and 2 yearsDiet × ABCG1 methylation interaction | interaction P < 0.05 for all |
CT-measured body fat distribution (VAT, SAT, deep SAT, total adipose tissue) · 6 months and 2 years
- Similar interaction patterns as for body weight and waist circumference
Original publication
DNA Methylation at ABCG1 and Long-term Changes in Adiposity and Fat Distribution in Response to Dietary Interventions: The POUNDS Lost Trial. Diabetes Care. Published 28 September 2023. doi:10.
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