Effects of dietary interventions and intermittent fasting on high-density lipoprotein (HDL) function in obese individuals with T2DM: a randomized controlled trial
Authors' conclusion
A balanced diet combined with meticulous insulin management improves multiple metrics of HDL function. While additional IF increases apoM levels, it does not further enhance other aspects of HDL functionality.
Study context
- Population
- Obese individuals with T2D on a standardized basal insulin regimen (INTERFAST-2 study)
- Participants
- 41 individuals
- Comparison
- IF (alternate-day fasting) plus dietary recommendations vs non-IF, both with standardized basal insulin
- IFn = 19
Primary result
As reported in the abstract
Serum apoM levels (within-group change) · 12 weeks
- IF: serum Apolipoprotein M (apoM) significantly elevated
- p = 0.0144
- non-IF: no increase in apoM
- p = 0.9801
Further findings
HDL cholesterol efflux capacity (within-group change) · 12 weeks
- Robust enhancement in both groups
- P < 0.0001, p = 0.0006
PON1 and lecithin cholesterol acyltransferase (LCAT) activity (within-group change) · 12 weeks
- non-IF: PON1 activity significantly elevated
- P = 0.0455
- non-IF: LCAT activity significantly elevated
- P = 0.0117
- IF: changes did not reach statistical significance
Original publication
Effects of dietary interventions and intermittent fasting on HDL function in obese individuals with T2DM: a randomized controlled trial. Cardiovasc Diabetol. Published 12 September 2024. doi:10.
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