Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study
Authors' conclusion
Our findings are consistent with other published literature supporting a role for choline metabolism in diabetes. Our study extends the current literature by analyzing a racially diverse population-based cohort of early middle-aged individuals in whom preventive activities may be most relevant.
Study context
- Population
- Adults aged 33–45 years free of DM at baseline, year 15 (2000–2001) of the CARDIA Study, racially diverse387 incident DM
- Participants
- 3,133 adults
- Exposure
- Plasma choline metabolites per 1-SD unit
- Outcome
- Incident DM
- Follow-up
- 15 years
Methodological detailspopulation-based, Cox proportional hazards regression adjusted for sociodemographics, health behaviors and clinical variables
- Population-based
- Cox proportional hazards regression adjusted for sociodemographics, health behaviors and clinical variables
Main finding
As reported in the abstract
Betaine, HR per 1-SD unit
0.76 (0.67, 0.88) (95% CI)
TMAO, HR per 1-SD unit
1.11 (1.01, 1.22) (95% CI)
Choline, HR per 1-SD (not significant)
1.05
0.94, 1.16
Observational data: associations, not effects.
Original publication
Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study. Diabetes Care. Published 11 September 2024. doi:10.
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