DNA Methylation Near CPT1A and Changes in Triglyceride-rich Lipoproteins in Response to Weight-loss Diet Interventions
Authors' conclusion
Participants with a higher regional DNAm level at CPT1A benefit more in long-term improvement in triglycerides, particularly in the TRLs and related apolipoproteins when consuming a low-fat weight-loss diet.
Study context
- Population
- White participants randomly assigned to 1 of 4 weight-loss diets varying in macronutrient components
- Participants
- 538 participants
- Comparison
- Low-fat vs high-fat weight-loss diet, by baseline regional DNA methylation at CPT1A
- Primary endpoint
- Association of baseline regional DNA methylation at CPT1A with change in total plasma TG
- Follow-up
- 2 years
Methodological details4 diets varying in macronutrient components
- 4 diets varying in macronutrient components
Primary result
As reported in the abstract
Higher regional DNA methylation at CPT1A and reduction in total plasma TG
- Low-fat diet: higher methylation associated with greater TG reduction
- P = .01
- High-fat diet: association
- P = .64
Further findings
Diet fat × methylation interaction for 2-year changes in very low-density lipoprotein (VLDL) lipids and apolipoproteins
- VLDL-triglycerides, P interaction
- .009
- VLDL-cholesterol, P interaction
- .002
- VLDL-apolipoprotein B, P interaction
- .016
- VLDL-apoC-III, P interaction (no interaction)
- .36
Original publication
DNA Methylation Near CPT1A and Changes in Triglyceride-rich Lipoproteins in Response to Weight-loss Diet Interventions. J Clin Endocrinol Metab. Published 17 February 2023. doi:10.
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